Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University

Bing He, PhD

Assistant Professor, School of Pharmaceutical Sciences, Peking University, China

Add: 38 Xueyuan Road, Haidian District, Beijing 100191

Short Bios

My research focuses on nanobiology and molecular pharmaceutics, with three directions: (1) elucidating the mechanisms of oral transcellular delivery for nanomedicines, (2) engineering metabolically active nano-adjuvants targeting the mevalonate pathway, and (3) developing innovative nano-drug delivery systems based on unique Nano-Bio interactions. As an individual PI, I have directed two NSFC individual grants (2026-2029, ¥RMB0.49M; 2018-2020, ¥RMB0.20M) and a Talent Support Program grant (2022-2025, ¥RMB1.9M). I have also directed a National Key Research and Development Program grant (2023-2026, ¥RMB1.4M) and two BNSF grants (2023-2027, ¥RMB1.0M; 2021-2024, ¥RMB0.35M) as a co-PI. As a corresponding author or first author, I have published 23 research articles in prestigious journals such as Nature Communications, Cell Reports Medicine, Science Advances, Advanced Materials, ACS Nano, Nano-Micro Letters, Nano Today, etc., accumulating over 5332 citations and an H-index of 44. Additionally, I have filed 4 domestic patents.

Education Background

2008—2012 Ph.D in Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, China

PI: Prof. Qiang Zhang (Academician of the Chinese Academy of Engineering)

2005—2007 M.S. in Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China

PI: Prof. Prof. Zhenping Wei

2001—2005 B.S., School of Chemical Engineering and Technology, Tianjin University, Tianjin, China

Academic Appointments

2019—Present Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, China

2016—2019 Research Associate, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, China

2013—2016 Postdoctoral Fellow, Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China

PI: Weigang Fang (Deputy Director of Peking University Health Science Center)

Teaching Experience

³ Pharmaceutics. ~80 undergraduate students annually, ~22 hours/year

Role: Lecturer; Audience: Undergraduates; Semester: 2019 Spring - Present; Institution: Peking University Health Science Center

³ Pharmaceutics Labs. ~120 undergraduate students annually, ~36 hours/year

Role: Lecturer; Audience: Undergraduates; Semester: 2019 Spring - Present; Institution: Peking University Health Science Center

³ Advanced Pharmaceutics. ~10 master’s students annually, ~24 hours/year

Role: Lecturer; Audience: Master’s students; Semester: 2024 Spring/Fall - Present; Institution: Peking University Health Science Center

³ Award: Outstanding Award, 21st Peking University Teaching Fundamentals Competition for Young Faculty Members (Medical Sciences Category) (2021)

Grants

³ General Program of the National Natural Science Foundation of China (NSFC) (82574340). Systematic analysis of the oral delivery mechanism of nanomedicines based on nano-proximity labeling technology. PI (2026-2029), ¥RMB 490,000.

³ The Young Top-Notch Talent Support Program. PI (2022-2025), ¥RMB 1,900,000.

³ National Natural Science Foundation of China (NSFC) Young Scientists Fund Project (81703441). Molecular regulatory mechanisms of nanocarrier transport across the multilevel intestinal mucosal barrier: a proteomics-based strategy. PI (2018-2020), ¥RMB 201,000.

³ Start-up Fund, PI (2019-2025), ¥RMB 1,000,000.

³ National Key Research and Development (NKRD) Program (2023YFC2605000). Development of therapeutics against highly pathogenic pathogens and platform technologies for advanced drug delivery systems. Co-PI (2023-2026), ¥RMB 1,400,000.

³ Key Research Special Project of Beijing Natural Science Foundation (BNSF) (Z230017). Computational design and druggability investigation of hypolipidemic lipoproteins. Co-PI (2023-2027), ¥RMB 1,000,000.

³ Major Basic Research Project of Shandong Provincial Natural Science Foundation (SDNSF) (ZR2023ZD25). Research on the preparation, activity screening, and novel nano-formulations of carbon quantum dots from authentic medicinal materials in Shandong. Co-PI (2024-2026), ¥RMB 400,000.

³ Key Laboratory Project of the National Medical Products Administration (NMPA) (2024ZDZ02). Investigation of the loading capacity and in vitro/in vivo drug release mechanisms of candesartan clexetil by amorphous mesoporous silica excipients. Co-PI (2024-2025), ¥RMB 200,000.

³ Beijing Natural Science Foundation - Haidian Original Innovation Joint Fund (BNSF-HOIJF) (L212013). Fundamental research on gastrointestinal transport mechanisms and biosecurity of oral nanoformulations for pediatric use. Co-PI (2021-2024), ¥RMB 350,000.

³ National Key Research and Development (NKRD) Program (2022YFA1206100). Research on nanotechnology for precise detection of oral microecological imbalance and synergistic pharmaceutical intervention. Role: Project Core Investigator (2023-2028), ¥RMB 1,200,000.

Publications

https://www.scopus.com/authid/detail.uri?authorId=57205669394&origin=resultslist

1. Meifang Chen, Xiaojia Jiao, Zhicheng Yan, Yueheng Wang, Jing Zhang, Qinghua Wu, Minghui Li, Shumin Fan, Yuan Wang, Wenbing Dai, Hua Zhang, Xueqing Wang, Qiang Zhang*, Bing He*, A nanosized metabolic reprogramming modulator sensitizes and amplifies innate immunity through the mevalonate-CoQ-OXPHOS/pyrimidine metabolism axis, Cell Reports Medicine. Accepted.

2. Yuhan Shen†, Shumin Fan†, Bing Wang, Kun Zhao, Song Wang, Kun Yan, Bing He*, Wei Yang*, Injectable Multifunctional Hydrogel Consisted of Ultrasonic Marker and Immune Adjust Agent in Liver Tumor Ablation: Animal Experiment’s Study, Cardiovasc. Intervent. Radiol. 2025, 2026, 49(2): 409–421

3. Yang Zhang†, Zhicheng Yan†, Shuo Geng†, Yueheng Wang, Junji Ren, Yunhui Jiang, Liuqing Yang, Wenbing Dai, Hua Zhang, Xueqing Wang, Nan Zheng*, Qiang Zhang*, Bing He*, A nanoscale innate immune multiplier amplifies immunogenic cell death triggered by oxaliplatin via enhancing systemic and trained immunity, Nano Today. 2025, 65: 102835.

4. Zhicheng Yan†, Bing Wang†, Yuhan Shen, Junji Ren, Meifang Chen, Yunhui Jiang, Hao Wu, Wenbing Dai, Hua Zhang, Xueqing Wang, Qiang Zhang*, Wei Yang*, Bing He*, Bisphosphonate-Mineralized Nano-IFNγ Suppresses Residual Tumor Growth Caused by Incomplete Radiofrequency Ablation through Metabolically Remodeling Tumor-Associated Macrophages, Theranostics. 2025, 15(3): 1057-1076.

5. Yan Feng†, Chenyang Liu†, Weiping Cui, Liuqing Yang, Di Wu, Hua Zhang, Xueqing Wang, Yuqian Sun, Bing He*, Wenbing Dai*, Qiang Zhang*, Engineering supramolecular peptide nanofibers for in vivo platelet-hitchhiking beyond ligand-receptor recognition, Sci. Adv. 2024, 10(43): eadq2072.

6. Junji Ren, Zibin Zhang, Shuo Geng, Yuxi Cheng, Huize Han, Zhipu Fan, Wenbing Dai, Hua, Zhang, Xueqing Wang, Qiang Zhang*, Bing He*, Molecular Mechanisms of Intracellular Delivery of Nanoparticles Monitored by an Enzyme-Induced Proximity Labeling, Nano-Micro Lett. 2024, 16: 103.

7. Ge Song†, Minghui Li†, Shumin Fan†, Mengmeng Qi, Bin Shao, Wenbing Dai, Hua Zhang, Xueqing Wang, Bing He*, Qiang Zhang*, Boosting synergism of chemo- and immuno-therapies via switching paclitaxelinduced apoptosis to mevalonate metabolism-triggered ferroptosis by bisphosphonate coordination lipid nanogranules. Acta Pharmaceutica Sinica. B. 2024, 14(2): 836-853.

8. Minghui Li†, Anna Jiang†, Huize Han, Meifang Chen, Bing Wang, Yuxi Cheng, Hua Zhang, Xueqing Wang, Wenbing Dai*, Wei Yang*, Qiang Zhang*, Bing He*, A Trinity Nano-Vaccine System with Spatiotemporal Immune Effect for the Adjuvant Cancer Therapy after Radiofrequency Ablation, ACS Nano. 2024, 18: 4590-4612.

9. Siyang Song, Xiangfu Guo, Zibin Zhang, Shumin Fan, Runyu Zhang, Zhicheng Yan, Qing Chen, Yang Song, Peiyao Wu, Chunling Wang, Yuxi Cheng, Lan Yuan, Hua Zhang, Wenbing Dai, Xueqing Wang, Bing He*, Qiang Zhang*, A universal strategy of facilitating intracellular delivery of nanomedicines based on tuning ARF6 GTPase to its GTP-bound form. Nano Today. 2023. 51: 101888.

10. Zibin Zhang, Junji Ren, Wenbing Dai, Hua Zhang, Xueqing Wang, Bing He*, Qiang Zhang*, Fast and Dynamic Mapping of the Protein Corona on Nanoparticle Surfaces by Photocatalytic Proximity Labeling. Adv. Mater. 2023: 2206636.

11. Yuxi Cheng, Junji Ren, Peiyao Wu, Yuxing Lin, Shaojie Lan, Wenbing Dai, Xueqing Wang, Hua Zhang, Bing He*, Qiang Zhang*, Nanoparticulates reduce tumor cell migration through affinity interactions with extracellular migrasomes and retraction fibers, Nanoscale Horiz. 2022. 7: 779-789.

12. Mengmeng Qin†, Minghui Li†, Ge Song, Canyu Yang, Peiyao Wu, Wenbing Dai, Hua Zhang, Xueqing Wang, Yiguang Wang, Demin Zhou, Bing He*, Qiang Zhang*, Boosting innate and adaptive antitumor immunity via a biocompatible and carrier-free nanovaccine engineered by the bisphosphonates-metal coordination, Nano Today. 2021, 37: 101097.

13. Jian Zhang, Mengmeng Qin, Dan Yang, Lan Yuan, Xiajuan Zou, Wenbing Dai, Hua Zhang, Xueqing Wang, Bing He*, Qiang Zhang*, Nanoprotein Interaction Atlas Reveals the Transport Pathway of Gold Nanoparticles across Epithelium and Its Association with Wnt β-Catenin Signaling, ACS Nano. 2021, 15: 17977-17997.

14. Minghui Li†, Mengmeng Qin†, Ge Song, Hailiang Deng, Dakuan Wang, Xueqing Wang, Wenbing Dai, Bing He*, Hua Zhang*, Qiang Zhang*, A biomimetic antitumor nanovaccine based on biocompatible calcium pyrophosphate and tumor cell membrane antigens, Asian J. Pharm. Sci. 2020, 16: 97-109.

15. Qing Chen, Guannan Guan, Feiyang Deng, Dan Yang, Peiyao Wu, Shuangming Kang, Ruimeng Sun, Xiaoyou Wang, Demin Zhou, Wenbing Dai, Xueqing Wang, Hua Zhang, Bing He*, Dawei Chen*, Qiang Zhang*, Anisotropic active ligandations in siRNA-Loaded hybrid nanodiscs lead to distinct carcinostatic outcomes by regulating nano-bio interactions, Biomaterials. 2020, 251: 120008.

16. Mengmeng Qin, Jian Zhang, Minghui Li, Dan Yang, Dechun Liu, Siyang Song, Jijun Fu, Hua Zhang, Wenbin Dai, Xueqing Wang, Yiguang Wang, Bing He*, Qiang Zhang*, Proteomic analysis of intracellular protein corona of nanoparticles elucidates nano-trafficking network and nano-bio interactions, Theranostics. 2020, 10(3): 1213-1229.

17. Dan Yang†, Dechun Liu†, Hailiang Deng, Jian Zhang, Mengmeng Qin, Lan Yuan, Xiajuan Zou, Bin Shao, Huiping Li, Wenbin Dai, Hua Zhang, Xueqing Wang, Bing He*, Xing Tang*, Qiang Zhang*, Transferrin Functionization Elevates transcytosis of Nanogranules across Epithelium by Triggering Polarity-Associated Transport Flow and Positive Cellular Feedback Loop, ACS Nano. 2019, 13(5): 5058-5076.

18. Tongkai Chen†, Bing He†, Jingsong Tao, Yuan He, Hailiang Deng, Xueqing Wang*, Ying Zheng*, Application of Forster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines, Adv. Drug Deliv. Rev. 2019, 143: 177-205.

19. Bing He, Yujie Shi, Yanqing Liang, Anpu Yang, Zhipu Fan, Lan Yuan, Xiajuan Zou, Xin Chang, Hua Zhang, Xueqing Wang, Wenbin Dai, Yiguang Wang, Qiang Zhang*, Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages, Nat. Commun. 2018, 9: 2393.

20. Dan Yang†, Dechun Liu†, Mengmeng Qin, Binlong Chen, Siyang Song, Wenbing Dai, Hua Zhang, Xueqing Wang, Yiguang Wang, Bing He*, Xing Tang*, Qiang Zhang*, Intestinal Mucin Induces More Endocytosis but Less Transcytosis of Nanoparticles across Enterocytes by Triggering Nanoclustering and Strengthening the Retrograde Pathway, Acs Appl. Mater. Interfaces. 2018, 10: 11443-11456.

21. Bing He, Lan Yuan, Wenbing Dai, Wei Gao, Hua Zhang, Xueqing Wang, Weigang Fang*, Qiang Zhang*, Dynamic bio-adhesion of polymer nanoparticles on MDCK epithelial cells and its impact on bio-membranes, endocytosis and paracytosis, Nanoscale. 2016, 8(11): 6129-6145.

22. Chao Yu†, Bing He†, Menghua Xiong, Hua Zhang, Lan Yuan, Ling Ma, Wenbing Dai, Jun Wang, Xinglin Wang, Xueqing Wang*, Qiang Zhang*, The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transport in epithelial MDCK cells, Biomaterials. 2013, 34(26): 6284-6298.

23. Bing He, Ping Lin, Zengrong Jia, Wenwen Du, Wei Qu, Lan Yuan, Wenbin Dai, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*, The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells., Biomaterials. 2013, 34(25): 6082-6098.

24. Bing He, Zengrong Jia, Wenwen Du, Chao Yu, Yuchen Fan, Wenbing Dai, Lan Yuan, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang*, The transport pathways of polymer nanoparticles in MDCK epithelial cells, Biomaterials. 2013, 34(17): 4309-4326.

Patents

1. Qiang Zhang, Bing He, Jinyin Zhang. A concentrated injectable formulation of β-elemene. Application Patent No.: 2026102008706. Feb 11, 2026.

2. Bing He, Yang Zhang, Zhicheng Yan, Shuo Geng, Qiang Zhang, Xueqing Wang, Hua Zhang, Wenbing Dai. Manganese bisphosphonate nanoparticles, their preparation method and application. Application Patent No.: 202510590966.3. May 8, 2025.

3. Bing He, Junji Ren, Qiang Zhang, Xueqing Wang, Hua Zhang, Wenbing Dai. A method for isolating and extracting proteins interacting with nanoparticles in living cells. Application Patent No.: 202311204286.0. Sep 19, 2023

4. Bing He, Zibin Zhang, Qiang Zhang, Xueqing Wang, Hua Zhang, Wenbing Dai. A rapid in-situ detection technology for nanoparticle-protein interactions based on photocatalysis. Application Patent No.: 202211051863.2. Aug 31, 2022.