王文靓  博士、助理教授、博士生导师

邮件：Wangwenliang92@bjmu.edu.cn

电话：+86 10 82801352

工作经历

2026.01~至今	北京大学	药学院药剂学系	助理教授（博导）
2021.02~2026.01	UT Austin	生物医用工程系	博士后
2019.09~2021.02	Johns Hopkins University	神经病学系	博士后

教育背景

2021.02~2026.01	UT Austin 导师：Dr.Huiliang(Evan) Wang	生物医用工程	博士后
2019.09~2021.02	Johns Hopkins University 导师：Dr.Ted M.Dawson  (美国医学院院士) & Dr.Xiaobo Mao	神经病学系	博士后
2014.09~2019.08	中国科学院长春应用化学研究所 导师：Dr.于喜飞	高分子化学与物理	博士
2010.09~2014.06	四川大学	高分材料系	学士

主要研究领域

a. 超声编程的分子控制技术（超声分子手术刀）。创新性提出并验证了 “超声分子手术刀”概念。 利用高频超声产生的机械应力精准驱动分子内部特定化学键的断裂和变化，实现了分子层面的可编程化操纵。同时，通过建立力学理论模型，将复杂的声力学过程转化为可预测精准分子激活，为开发新型超声响应药物递送系统及纳米诊疗装备提供了核心技术支撑，在精准医疗领域具有极高的临床转化潜力。(Nature, 2025, 638, 401-410)

b. 聚焦超声介导的非侵入式神经调节和监测（声化学遗传学与声光遗传学）。精准的神经元活动控制为大脑神经网络解析以及疾病治疗提供了有力手段，但临床应用受限于侵入性手术以及低效的神经信号监测。相关研究集中于超声响应药物的构建以及可穿戴的超声系统开发，实现非侵入的远程深脑神经控制，并研究其在脑机接口，神经疾病治疗等领域的应用。(J. Am. Chem. Soc. 2023, 145, 2, 1097–1107; ACS nano, 2023, 17, 24936-24946; Adv. Drug Deliv. Rev. 2022, 186, 114343)

c. 开发细胞膜仿生的基因递送体系，实现高效的神经元表达。设计合成了细胞膜仿生的新型脂质体材料—胆碱磷酸。通过将磷脂分子头部基团“磷脂酰-胆碱”两性离子基团在空间排列次序进行取向移位，首次合成出了高纯度的胆碱磷酸分子，并开发用于基因、药物的靶向高效递送。该工作从分子结构上革新了脂质体，实现了功能化人造细胞膜的有效合成控制。( Chem. Mater. 2023, 35 (12), 4587–4597; Chem. Mater. 2021, 33 (2), 774–781; Nano letters, 2023, 23, 9310–9318)

部分荣誉奖励

2025	Materials Research Society	最佳报告奖
2023	美国深脑刺激协会	Rising star award
2019	中国科学院	优秀应届毕业生
2018	中国科学院	研究生国家奖学金
2013	四川大学	优秀学生奖学金

已发表论文(#表示这些作者对本论文的贡献相同)

第一作者文章

1.      Wang, W.; Shi, Y.; Chai, W.; Tang, K.; Pyatnitskiy, I.; Liu, X.; Shi, X.; Jeong, J.; Lozano, A.; Artman, B,; Henkelman, G.; Chen, B.; Wang, H. H-bonded organic frameworks as ultrasound programmable delivery platform. Nature, 2025, 638, 401-410 https://www.nature.com/articles/s41586-024-08401-0#Sec21

2.      Wang, W.; Wu, X.; Tang, K.; Pyatnitskiy, I.; Liu, X.; Shi, X.; Jeong, J.; Lozano, A.; Artman, B,; Fenno, L.; Buch, V.; Wang, H. Sono-optogenetic deep brain stimulation via self-amplifying liposomal nanotransducer. ACS nano, 2023, 17, 24936-24946. https://pubs.acs.org/doi/10.1021/acsnano.3c06577

3.      Wang, W.; Tasset, A.; Pyatnitskiy, I.; Lin, P.; Bellamkonda, A.; Metha, R.; Gabbert, C.; Yuan, F.; Peppas, N.; Wang, H. Reversible, covalent DNA condensation approach using chemical linkers for enhanced gene delivery. Nano letters, 2023, 23, 9310–9318

4.      Wang, W.; Wu, X.; Tang, K.; Pyatnitskiy, I.; Taniguchi, R.; Zhou, R.; Lin, P.; Capocyan, S. L. C.; Hong, G.; Wang, H. Ultrasound-Triggered In Situ Photon Emission for Noninvasive Optogenetics. J. Am. Chem. Soc. 2023, 145, 2, 1097–1107. https://pubs.acs.org/doi/10.1021/jacs.2c10666

5.      Wang, W.; Tasset, A.; Pyatnitskiy, I.; Mohamed, H. G.; Taniguchi, R.; Zhou, R.; Rana, M.; Lin, P.; Capocyan, S. L. C.; Bellamkonda, A.; Chase Sanders, W.; Wang, H. Ultrasound Triggered Organic Mechanoluminescence Materials. Adv. Drug Deliv. Rev. 2022, 186, 114343.

6.      Wang, W.; Jiang, S.; Li, S.; Yan, X.; Liu, S.; Mao, X.; Yu, X. Functional Choline Phosphate Lipids for Enhanced Drug Delivery in Cancer Therapy. Chem. Mater. 2021, 33 (2), 774–781.

7.      Wang, W.; Liu, S.; Chen, B.; Yan, X.; Li, S.; Ma, X.; Yu, X. DNA-Inspired Adhesive Hydrogels Based on the Biodegradable Polyphosphoesters Tackified by a Nucleobase. Biomacromolecules 2019, 20 (10), 3672–3683.

8.      Wang, W.; Lin, L.; Ma, X.; Wang, B.; Liu, S.; Yan, X.; Li, S.; Tian, H.; Yu, X. Light-Induced Hypoxia-Triggered Living Nanocarriers for Synergistic Cancer Therapy. ACS Appl. Mater. Interfaces 2018, 10 (23), 19398–19407.

9.      Wang, W.; Wang, B.; Liu, S.; Shang, X.; Yan, X.; Liu, Z.; Ma, X.; Yu, X. Bioreducible Polymer Nanocarrier Based on Multivalent Choline Phosphate for Enhanced Cellular Uptake and Intracellular Delivery of Doxorubicin. ACS Appl. Mater. Interfaces 2017, 9 (19), 15986–15994.

10.   Wang, W.; Wang, B.; Ma, X.; Liu, S.; Shang, X.; Yu, X. Tailor-Made pH-Responsive Poly(choline Phosphate) Prodrug as a Drug Delivery System for Rapid Cellular Internalization. Biomacromolecules 2016, 17 (6), 2223–2232.

11.   Wang, W.; Ma, X.; Yu, X. pH-Responsive Polymersome Based on PMCP-B-PDPA as a Drug Delivery System to Enhance Cellular Internalization and Intracellular Drug Release. Chin. J. Polym. Sci. 2017, 35 (11), 1352–1362.

12.   Jiang, S.; Wang, W.*; Dong, L.; Yan, X.; Li, S.; Mei, W.; Xie, X.; Zhang, Y.; Liu, S.; Yu, X. Infrared Responsive Choline Phosphate Lipids for Synergistic Cancer Therapy. Chem. Eur. J. 2021, 27 (49), 12589–12598.

 

共同作者文章:

 

1.   Li, S.; Yan, X.; Qu, Y.; Wang, W.; Chen, B.; Ma, X.; Liu, S.; Yu, X. Hydrogen-Bond Cyclization Programming of Ultrasensitive Esters and Its Application in Gene Delivery. Chem. Eur. J. 2019, 25 (44), 10375–10384.

2.   Li, S.; Lin, L.; Wang, W.; Yan, X.; Chen, B.; Jiang, S.; Liu, S.; Ma, X.; Tian, H.; Yu, X. Aza-Crown Ether Locked on Polyethyleneimine: Solving the Contradiction between Transfection Efficiency and Safety during in Vivo Gene Delivery. Chem. Commun. 2020, 56 (41), 5552–5555.

3.   Jia, L.; Liu, Y.; Wang, W.; Wang, Y.; Liu, H.; Liu, F.; Chen, R.; Dawson, V. L.; Dawson, T. M.; Lu, F.;            Liu, L.; Wang, Y.; Mao, X. Molecular Mediation of Prion-like α-Synuclein Fibrillation from Toxic PFFs to Nontoxic Species. ACS Appl. Bio. Mater. 2020, 3 (9), 6096–6102.

4.   Hsieh, J.-C.; Alawieh, H.; Li, Y.; Iwane, F.; Zhao, L.; Anderson, R.; Abdullah, S. I.; Kevin Tang, K. W.; Wang, W.; Pyatnitskiy, I.; Jia, Y.; Millán, J. D. R.; Wang, H. A Highly Stable Electrode with Low Electrode-Skin Impedance for Wearable Brain-Computer Interface. Biosens. Bioelectron. 2022, 218, 114756.

5.   Li, S.; Wang, W.; Yu, X. A Perspective of Engineered Lipids and Liposomes: Chemical Design and Functional Application Based on Therapeutic Safety. Chem. Mater. 2023, 35 (12), 4587–4597.

6.   Hsieh, J.-C.; He, W.; Venkatraghavan, D.; Koptelova, V. B.; Ahmad, Z. J.; Pyatnitskiy, I.; Wang, W.; Jeong, J.; Tang, K. K. W.; Harmeier, C.; Li, C.; Rana, M.; Iyer, S.; Nayak, E.; Ding, H.; Modur, P.; Mysliwiec, V.; Schnyer, D. M.; Baird, B.; Wang, H. Design of an Injectable, Self-Adhesive, and Highly Stable Hydrogel Electrode for Sleep Recording. Device 2024, 2 (2), 100182.

专利

中国专利一项，美国专利4项（申请中）

1.      Yu, X., Liu, S., Wang, W., Li, S., Jiang, S., liposome, preparation method thereof, liposome assembly and

loaded liposome complex: CN. Patent Application, CN110540551A.

2.      Wang, H., Wang, W., Tasset, A., Reversible, covalent DNA condensation approach via chemical linkers for

 enhanced gene delivery: U.S. Patent Application, PCT/US2023/027025, submitted.

3.      Wang, H., Wang, W., Shi, Y., Chen, B., Ultrasound programmable hydrogen-bonded organic

frameworks for spatiotemporal control of drug release: U.S. Patent Application, PCT/US2024/042314, submitted.

4.      Wang, H., Wang, W., Piatnitskii, I., Hydrogen-Bonded Frameworks Nanoparticles for Sono-Optogenetic

Treatment of Brain Disease: U.S. Patent Application, PCT/US2024/058476, submitted.

5.      Wang, H., Wang, W., Hong, G., Wu, X., Ultrasound triggered liposome light source for non-

invasive optogenetics: U.S. Patent Application,63/519,490, submitted.

其他经历

u  美国心脏协会会员（2020.9-今）

u  美国癌症研究协会会员（2021.07-今）

u  Frontiers 系列期刊的客座编辑

u  Brain-X 期刊青年编委